Anti-aging activity of Korean pine ( Pinus koraiensis ) leaf extracts demonstrated through the induction of mitochondrial biogenesis in mice
Year: 2013
Type: article
Abstract: Age-related increases in cellular damage and death have been associated with oxidative stress. Mitochondrial biogenesis is likely to be involved in the regulation of cell metabolism and signal transduction. In addition, there is a growing body of evidence suggesting that mitochondrial biogenesis is a key regulator of mitochondrial reactive oxygen species (ROS). Our results demonstrate that Pinus koraiensis leaf (PKL) extract reduces oxidative stress and, at the same time, stimulates the proliferation of mitochondria through a peroxisome proliferation-activated receptor coactivator 1 α (PGC-1α) signaling pathway. The effects of PKLs were associated with the induction of genes associated with oxidative phosphorylation and mitochondrial biogenesis pathways, and were largely explained by PKLmediated decrease in PGC-1α acetylation and an increase in PGC-1α activity. PKL extracts induced a PGC-1α dependent pathway in mitochondria capable of efficient and balanced bioenergetics to reduce oxidative stress and attenuate endogenous oxidative damage.
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2114256775