Race modifies the association between adiposity and inflammation in patients with chronic kidney disease: Findings from the chronic renal insufficiency cohort study
Year: 2014
Type: article
Abstract: OBJECTIVE: The race-specific association of inflammation with adiposity and muscle mass in subjects with chronic kidney disease (CKD) was examined. METHODS: Plasma concentration of interleukin (IL)-1β, IL-1 receptor antagonist (IL-1RA), IL-6, IL-10, tumor necrosis factor (TNF)-α, TGF-β, high-sensitivity C-reactive protein (hs-CRP), fibrinogen, and serum albumin was measured in 3,939 Chronic Renal Insufficiency Cohort study participants. Bioelectric impedance analysis was used to determine body fat mass (BFM) and fat-free mass (FFM). RESULTS: Plasma levels of hs-CRP, fibrinogen, IL-1RA, IL-6, and TNF-α increased and serum albumin decreased across the quartiles of body mass index. In multivariable analysis, BFM and FFM were positively associated with hs-CRP, fibrinogen, IL-1β, IL-1RA, and IL-6. One standard deviation (SD) increase in BFM and FFM was associated with 0.36 (95% confidence interval [CI] = 0.33, 0.39) and 0.26 (95% CI = 0.22, 0.30) SD increase in log-transformed hs-CRP, respectively (P < 0.001). Race stratified analysis showed that the association between biomarkers and BFM and FFM differed by race, with Caucasians, demonstrating a stronger association with markers of inflammation than African Americans. CONCLUSIONS: BFA and FFM are positively associated with markers of inflammation in patients with CKD. Race stratified analysis showed that Caucasians have a stronger association with markers of inflammation compared to African Americans.
Source: Obesity
DOI: 10.1002/oby.20692
Authors: Maria R. Wing, Wei Yang, Valerie Teal, Sankar Navaneethan, Kaixiang Tao, Akinlolu Ojo, Nicolas N. Guzman, Muredach Reilly, Melanie Wolman, Sylvia E. Rosas, Magda Cuevas, Michael Fischer, Eva Lustigova, Stephen R. Master, Dawei Xie, Dina Appleby, Marshall Joffe, John Kusek, Harold I Feldman, Dominic S. Raj, for the Chronic Renal Insufficiency Cohort (CRIC) Study
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Clinical and Translational Science Institute, G1965526657, G2063336705, Case Western Reserve University/Cleveland Clinic CTSA (UL1), Institute for Clinical and Translational Research (UL1), Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study, General Clinical Research Center, Michigan Institute for Clinical and Health Research (MICHR) (UL1), Institutional Clinical and Translational Science Award, Anti-inflammatory Therapy in Diabetic CKD, Center for Clinical and Translational Science, Clinical and Translational Science Institute, GENERAL CLINICAL RESEARCH CENTER, Gut Microbiota and Atherosclerosis in ESRD, Cytokine Gene Polymorphism in CRIC Cohort, General Clinical Research Center, Clinical and Translational Science Collaborative of Cleveland, G9000141709, Prospective renal insufficiency cohort evaluation: PRICE, Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center, Continuation of the University of Illinois Chicago CRIC Clinical Center, Tulane Clinical Center for Chronic Renal Insufficiency Cohort Study, Chronic Renal Insufficiency Cohort Limited competition continuation, Chronic Renal Insufficiency Cohort (CRIC) Study
OpenAlex ID: W2114385966