Recent Advances in the Discovery and Preclinical Testing of Novel Compounds for the Prevention and/or Treatment of Alcohol Use Disorders
Year: 2012
Type: review
Abstract: Alcohol abuse and dependence have a staggering socioeconomic impact, yet current therapeutic strategies are largely inadequate to treat these disorders. Thus, the development of new strategies that can effectively prevent alcohol use disorders (AUDs) is of paramount importance. Currently approved medications attempt to deter alcohol intake by blocking ethanol metabolism or by targeting the neurochemical systems downstream of the cascades leading to craving and dependence. Unfortunately, these medications have provided only limited success as indicated by the continued high rates of alcohol abuse and alcoholism. The lack of currently available effective treatment strategies is highlighted by the urgent call by the NIAAA to find new and paradigm-changing therapeutics to either prevent or treat alcohol-related problems. This mini-review highlights recent findings from 4 laboratories with a focus on compounds that have the potential to be novel therapeutic agents that can be developed for the prevention and/or treatment of AUDs.
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G117160461, G1325570693, Neurosteroid Modulation of Ethanol Withdrawal Severity, G1485104189, G2371743950, The Neurotrophic Factor GDNF and Alcohol Addiction, Integrative Neuroscience Initiative on Alcoholism, G3955691050, G4069708318, Neurochemical Manipulation of Withdrawal-Induced Drinking, G4826363899, Sites and Mechanisms of Ethanol Action in P2X receptors, Integrative Neuroscience Initiative on Alcoholism, G5831713003, G5877021771, G5901500984, BIOLOGICAL BASES OF ALCOHOLISM
OpenAlex ID: W2114457069