Work

Cell-derived microparticles in haemostasis and vascular medicine

Year: 2009

Type: article

Abstract: Considerable interest for cell-derived microparticles has emerged, pointing out their essential role in haemostatic response and their potential as disease markers, but also their implication in a wide range of physiological and pathological processes. They derive from different cell types including platelets - the main source of microparticles - but also from red blood cells, leukocytes and endothelial cells, and they circulate in blood. Despite difficulties encountered in analyzing them and disparities of results obtained with a wide range of methods, microparticle generation processes are now better understood. However, a generally admitted definition of microparticles is currently lacking. For all these reasons we decided to review the literature regarding microparticles in their widest definition, including ectosomes and exosomes, and to focus mainly on their role in haemostasis and vascular medicine.

Source: Thrombosis and Haemostasis

DOI: 10.1160/th08-08-0521

Authors: Laurent Burnier, Pierre Fontana, Brenda R. Kwak, Anne Angelillo-Scherrer

Institutions: Centre Hospitalier Universitaire Vaudois, University of Lausanne, University of Geneva, University Hospital of Geneva

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2114495365

FWCI: 11.48

Cites: 172

Cited by: 422

Related to: 10