Work

Binding of Glucuronoxylomannan to the CD14 Receptor in Human A549 Alveolar Cells Induces Interleukin-8 Production

Year: 2006

Type: article

Abstract: Glucuronoxylomannan (GXM) is the major capsular polysaccharide of Cryptococcus neoformans. GXM receptors have been characterized in phagocytes and endothelial cells, but epithelial molecules recognizing the polysaccharide remain unknown. In the current study, we demonstrate that GXM binds to the CD14 receptor in human type II alveolar epithelial cells, resulting in the production of the proinflammatory chemokine interleukin-8.

Source: Clinical and Vaccine Immunology

DOI: 10.1128/cvi.00296-06

Authors: Fabiane M. Barbosa, Fernanda L. Fonseca, Rodrigo T. Figueiredo, Marcelo T. Bozza, Arturo Casadevall, Leonardo Nimrichter, Marcio L. Rodrigues

Institutions: Universidade Federal do Rio de Janeiro, Albert Einstein College of Medicine

Language: English

Topic: Fungal Infections and Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases

Awards: G1593697378, G1750079537, G2019266947, G2436179761, Synergy of Host Defense Mechanisms in the Lung, G2773611754, G3501732833, G4559384, G4617214234, Protective antibodies for Cryptococcal Infections, Biology of Fungal Melanin, Molecular Characterization of C. neoformans Antibodies

OpenAlex ID: W2114574592

FWCI: 1.106

Cites: 26

Cited by: 33

Related to: 10