Work

Synthetically Programmable DNA Binding Domains in Aggregates of DNA‐Functionalized Gold Nanoparticles

Year: 2009

Type: article

Abstract: Nanoparticles that assemble into core/shell aggregate structures comprising thermally addressable, phase-separated DNA binding domains are designed. Since the strength of the DNA binding in these domains differs, these aggregate systems exhibit two distinct melting transitions upon dehybridization (see image) resulting from the stepwise disassociation of the entire structure. These materials are ideal for probing the structure–function relationship of DNA-linked nanoparticle aggregates.

Source: Small

DOI: 10.1002/smll.200900568

Authors: Sarah J. Hurst, Haley D. Hill, Robert J. Macfarlane, Jinsong Wu, Vinayak P. Dravid, Chad A. Mirkin

Institutions: Northwestern University, International Institute for Nanotechnology

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Cancer Institute

Award: Nanomaterials for Cancer Diagnostics and Therapeutics