Work

Studying gene function in Caenorhabditis elegans using RNA-mediated interference

Year: 2008

Type: review

Abstract: The RNA interference (RNAi) method for targeted gene silencing is widely used in Caenorhabditis elegans for large-scale functional genomic studies, analysis of limited gene sets and detailed analysis of individual gene function. The application of RNAi has identified genes that participate in various aspects of development, physiology and cell biology. In addition, RNAi has been used to identify interacting genes and to study functionally redundant genes. This review discusses the various applications of RNAi in C. elegans, focusing particularly on the analysis of developmental processes.

Source: Briefings in Functional Genomics and Proteomics

DOI: 10.1093/bfgp/eln019

Author: E. M. Maine

Institution: Syracuse University

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Science Foundation

OpenAlex ID: W2114760935

FWCI: 0.155

Cites: 96

Cited by: 19

Related to: 10