Helicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation

Year: 2002

Type: article

Abstract: Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.

Source: Science

DOI: 10.1126/science.1069076

Institutions: Umeå University, University of Gothenburg, University of Tartu, Lund University, Washington University in St. Louis, Uniformed Services University of the Health Sciences, Linköping University, Swedish University of Agricultural Sciences, Karolinska Institutet

Language: English

Topic: Helicobacter pylori-related gastroenterology studies

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: H. PYLORI INFECTION AND GI DISEASE IN ALASKA NATIVES, Bacterial and Chemical Carcinogens in Gastric Oncogenesis, Molecular Genetics of H. Pylori In India, DRUG RESISTANCE AND GENE TRANSFER IN H PYLORI, Host-environment interactions in the pathophysiology of digestive disease

OpenAlex ID: W2114798556