Work

Mitochondria-Associated Endoplasmic Reticulum Membranes in Insulin Signaling

Year: 2014

Type: article

Abstract: Hepatic insulin resistance is a key feature of type 2 diabetes, and the consequent dysregulation of glucose and lipid output from the liver are important contributors to the observed hyperglycemia and hyperlipidemia. While excessive lipid accumulation and defective signaling by protein kinase C have been implicated in the past, the full panoply of molecular mechanisms involved is still not defined. Deeper insights would therefore be welcome in the quest to identify new therapeutic approaches to the disease.

Source: Diabetes

DOI: 10.2337/db14-0812

Authors: Guy A. Rutter, Paolo Pinton

Institutions: Hammersmith Hospital, Imperial College London, University of Ferrara

Language: English

Topic: Metabolism, Diabetes, and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Wellcome Trust, Medical Research Council, Biotechnology and Biological Sciences Research Council