Work

Synthesis of 64CuII–Bis(dithiocarbamatebisphosphonate) and Its Conjugation with Superparamagnetic Iron Oxide Nanoparticles: In Vivo Evaluation as Dual‐Modality PET–MRI Agent

Year: 2011

Type: article

Abstract: A novel bifunctional chelator combines a dithiocarbamate group for binding the positron-emitter 64Cu (red spheres) for PET imaging and a bisphosphonate group (green ellipsoids) for strong binding to several inorganic materials, such as MRI contrast agents based on superparamagnetic iron oxide nanoparticles and rare-earth metal oxides. The dual PET–MR imaging capabilities of this approach are demonstrated in vivo by imaging lymph nodes using both imaging modalities.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201007894