Work

Increased anxiety of mice lacking the serotonin 1A receptor

Year: 1998

Type: article

Abstract: Brain serotonin (5-HT) has been implicated in a number of physiological processes and pathological conditions. These effects are mediated by at least 14 different 5-HT receptors. We have inactivated the gene encoding the 5-HT1A receptor in mice and found that receptor-deficient animals have an increased tendency to avoid a novel and fearful environment and to escape a stressful situation, behaviors consistent with an increased anxiety and stress response. Based on the role of the 5-HT1A receptor in the feedback regulation of the 5-HT system, we hypothesize that an increased serotonergic neurotransmission is responsible for the anxiety-like behavior of receptor-deficient animals. This view is consistent with earlier studies showing that pharmacological activation of the 5-HT system is anxiogenic in animal models and also in humans.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.95.18.10734

Authors: Christopher L. Parks, Patricia S. Robinson, Etienne Sibille, Thomas Shenk, Miklos Toth

Institutions: Howard Hughes Medical Institute, Princeton University, Cornell University

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2115182798

FWCI: 9.305

Cites: 57

Cited by: 702

Related to: 10