Human Immunodeficiency Virus Type 2 Vpx-Gag Interaction
Year: 1998
Type: article
Abstract: Incorporation of Vpx into human immunodeficiency virus type 2 (HIV-2) virus-like particles is mediated by the Gag polyprotein. We have identified residues 15 to 40 of Gag p6 and residues 73 to 89 of Vpx as being necessary for virion incorporation. In addition, we show enhanced in vitro binding of Vpx to a chimeric HIV-1/HIV-2 Gag construct containing residues 2 to 49 of HIV-2 p6 and demonstrate that the presence of residues 73 to 89 of Vpx allows for in vitro binding to HIV-2 Gag.
Source: Journal of Virology
Authors: Heather A. Pancio, Lee Ratner
Institution: Washington University in St. Louis
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Funder: U.S. Public Health Service
Awards: G3547314113, G3938405329, G7521391657
OpenAlex ID: W2115187431