Year: 2010
Type: article
Study design: Observational Study
Abstract: Despite twin studies showing that 50-70% of variation in DSM-IV cannabis dependence is attributable to heritable influences, little is known of specific genotypes that influence vulnerability to cannabis dependence. We conducted a genome-wide association study of DSM-IV cannabis dependence. Association analyses of 708 DSM-IV cannabis-dependent cases with 2346 cannabis-exposed non-dependent controls was conducted using logistic regression in PLINK. None of the 948 142 single nucleotide polymorphisms met genome-wide significance (P at E-8). The lowest P values were obtained for polymorphisms on chromosome 17 (rs1019238 and rs1431318, P values at E-7) in the ANKFN1 gene. While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence.
Source: Addiction Biology
Authors: Arpana Agrawal, Michael T. Lynskey, Anthony Hinrichs, Richard Grucza, Scott F. Saccone, Robert Krueger, Rosalind Neuman, William Howells, Sherri Fisher, Louis Fox, Robert Cloninger, Danielle M. Dick, Kimberly F. Doheny, Howard J. Edenberg, Alison M. Goate, Victor Hesselbrock, Eric Johnson, John Kramer, Samuel Kuperman, John I. Nurnberger Jr., Elizabeth Pugh, Marc Schuckit, Jay Tischfield, John P. Rice, Kathleen K. Bucholz, Laura J. Bierut
Institutions: Washington University in St. Louis, Virginia Commonwealth University, Johns Hopkins University, Johns Hopkins Medicine, Indiana University School of Medicine, University of Connecticut, RTI International, University of Iowa, University of Iowa Hospitals and Clinics, University of California San Diego, Rutgers, The State University of New Jersey
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Awards: G1083756078, G1498645941, EARLY SUBSTANCE USE AND ADDICTION: GENES, ENVIRONMENT, AND EPIDEMIOLOGY, G1645697759, G1654839069, G1669123918, G2050042542, G2146332128, G2481876672, Study of Addiction: Genetics and Environment, G3063849715, G363841575, G3799582765, G3881253148, G4503763930, Genome Wide Association Coordinating Center, G5644307350, FAMILY STUDY OF COCAINE DEPENDENCE, G7093047072, G8267674335, G858805679, G8879572479, G9000024769, G9000025954, G9000054071, G9000134904, G9000176579, G9000327125
OpenAlex ID: W2115207541