Year: 2014
Type: dissertation
Abstract: __abstract__ \n \nThe immune system is capable to detect a large variability of pathogens and distinguish \nthem from the body’s own healthy tissue. The immune system consists of the innate- and \nadaptive immune system. The adaptive immune system consists of B-and T-lymphocytes, \nwhich can recognize pathogens with an antigen-specific receptor. B-lymphocytes can \nadapt their responses during an infection to improve recognition of the pathogen and \nthey generate long-term immunological memory. These antigen-specific receptors are \ncalled B-cell receptor (BR) and T-cell receptor (TR), respectively. Since the number of possible \nantigens is innumerable, an enormous diversity of the antigen-specific receptors is \nrequired. To achieve this, the BR and TR contain a variable domain that is unique for each \nindividual T or B cell. This variable domain is generated by recombination of the antigen \nreceptor genes in a process which is called V(D)
Author: Hanna IJspeert
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2115219447