Year: 2000
Type: article
Abstract: Diabetes mellitus, whether type 1 (insulindependent diabetes mellitus; IDDM) or type 2 (noninsulin-dependent diabetes mellitus; NIDDM) results from an inadequate mass of functional pancreatic -cells. In the first case, the -cell mass is reduced by the autoimmune destruction of the -cells, while, in the latter, there is incomplete compensation to meet the demand often imposed by insulin resistance. This latter point is not always appreciated. However, only 20% of those people with severe insulin resistance due to obesity, Cushing’s disease, or acromegaly become diabetic, with the other 80% being able to compensate to
Author: S Bonner-Weir
Institution: Joslin Diabetes Center
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2115259598