A 3p26-3p25 Genetic Linkage Finding for DSM-IV Major Depression in Heavy Smoking Families
Year: 2011
Type: article
Abstract: OBJECTIVE: The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking. METHOD: Within a study that targeted families characterized by a history of smoking, analyses derived a subset of 91 Australian families with two or more offspring with a history of DSM-IV major depressive disorder (affected sibling pairs, N=187) and 25 Finnish families (affected sibling pairs, N=33). Within this affected sibling pairs design, the authors conducted nonparametric linkage analysis. RESULTS: In the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25). CONCLUSIONS: Genome-wide significant linkage was detected for major depressive disorder on chromosome 3p in a sample ascertained for smoking. A linkage peak at this location was also observed in an independent study of major depressive disorder.
Source: American Journal of Psychiatry
Authors: Michele L. Pergadia, Anne L. Glowinski, Naomi R. Wray, Arpana Agrawal, Scott F. Saccone, Anu Loukola, Ulla Broms, Tellervo Korhonen, Brenda W.J.H. Penninx, Julia D. Grant, Elliot C. Nelson, Anjali K. Henders, Andrew J. Schrage, Yi-Ling Chou, Kaisu Keskitalo-Vuokko, Qin Zhu, Scott D. Gordon, Jacqueline M. Vink, Eco J.C. de Geus, Stuart MacGregor, Jimmy Z. Liu, Gonneke Willemsen, Sarah E. Medland, Dorret I. Boomsma, Grant W. Montgomery, John P. Rice, Alison M. Goate, Andrew C. Heath, Jaakko Kaprio, Nicholas G. Martin, Pamela A.F. Madden
Institutions: University of Helsinki, Washington University in St. Louis, QIMR Berghofer Medical Research Institute, Finnish Institute for Health and Welfare, Amsterdam Public Health, Institute for Molecular Medicine Finland, Vrije Universiteit Amsterdam, Amsterdam UMC Location Vrije Universiteit Amsterdam
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Awards: G120436993, DETECTING SUSCEPTIBILITY LOCI FOR RECURRENT DEPRESSION, G1335377886, The Genetics of Vulnerability to Nicotine Addictions, G1398898637, G1738478728, G1750301750, G2050042542, G2266941569, G2328879485, G238373470, BROWN CENTER FOR VIOLENCE AND INJURY PREVENTION, G2561471519, G294002421, G3063849715, Adolescents at High Risk For Familial Bipolar Disorder, G338608737, MARC: Genetic Epidemiology of Alcoholism & Comorbidity, G3548961933, G3593425801, G3619332945, G3641117142, G3962587703, RESEARCH EDUCATION PROGRAM ON COMPUTATIONAL AND STATISTICAL TOOL DEVELOPMENT FOR ADDICTION GENETICS, G412057792, G425717312, GENETIC AND EPIDEMIOLOGICAL MODELS OF ALCOHOL ABUSE, G4471409110, G5081769567, Biomedical Training in Alcoholism Research, G6129226368, ALCOHOL USE DISORDER IN YOUNG WOMEN: GENETIC EPIDEMIOLOGY: MOAFTS WAVE 7, G8263226176, G8278726054, G8411077182, G8457999026, Major Depression: Stage 1 Genomewide Association in Population-Based Samples, G8879572479, G958452887, G977574824
OpenAlex ID: W2115406068