Year: 1980
Type: article
Abstract: Polypeptide hormones, growth factors, and a variety of other naturally occurring ligands bind specifically to receptors on the cell surface. At physiologic temperatures these ligands are internalized by cells and associate intracellularly with lysosomes. Receptor-mediated internalization provides a simple mechanism that may act to couple receptor-mediated hormone degradation with receptor-medicated receptor regulation.
DOI: 10.1177/28.8.6255030
Authors: P Gorden, J L Carpentier, P Freychet, L Orci
Institution: National Institutes of Health
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2115461765