Work

Bone tissue engineering using synthetic fibrin-like hydrogels

Year: 2008

Type: article

Abstract: matrices (ECM) represent interesting alternatives for biopolymers as they can be specifically designed with respect to their mechanical properties, susceptibility to degradation and presentation of cell adhesion ligands or morphogens. Here we present modularly designed poly(ethylene glycol) (PEG)-based hydrogels that are formed by Factor XIII (FXIII) catalysis. The new class of biomaterials enables the formation of matrices containing multiple tethered bioactive molecules and cell-responsive enzymatic substrates in a simple one step reaction. In the context of bone tissue engineering we have designed the system to contain building blocks that include enzymatically coupled cell adhesion ligands, the

Authors: Franz E. Weber, Mathias P. Lutolf, Simone C. Rizzi, Jeffrey A. Hubbell, Martin Ehrbar

Institutions: University of Zurich, École Polytechnique Fédérale de Lausanne, Queensland University of Technology

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

OpenAlex ID: W2115576340

FWCI:

Cites: 2

Cited by:

Related to: 10