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Biologically targeted probes for Zn 2+ : a diversity oriented modular “click-S N Ar-click” approach

Year: 2014
Type: article
Abstract: co-released when the pancreatic beta cells were stimulated to release insulin. Conversely, sensors that target intracellular compartments were unaffected. These results demonstrate that this sensor has the potential to allow the real time study of insulin release from living cells and exemplifies the utility of our simple synthetic approach.
DOI: 10.1039/c4sc01249f
Authors: J. Pancholi, D. J. Hodson, K. Jobe, G. A. Rutter, S. M. Goldup, M. Watkinson
Language: English
Subfield: Spectroscopy
Field: Chemistry
Open Access status: hybrid
Funders: Wellcome Trust, European Federation of Pharmaceutical Industries and Associations, Diabetes UK, European Commission, Innovative Medicines Initiative, Medical Research Council, Engineering and Physical Sciences Research Council
Awards: Roles of GWA genes in controlling pancreatic beta cell function and mass., G2040450235, Control of glucagon secretion by AMPK and related kinases., G3207356259, G3253699505, In situ imaging of beta cell function in mice deleted for Type 2 diabetes-associated genes, G3555667338, G6100787592
OpenAlex ID: W2115735714
FWCI: 2.956
Cites: 92
Cited by: 53
Related to: 10