Work

Enantioselective Functionalization of Radical Intermediates in Redox Catalysis: Copper‐Catalyzed Asymmetric Oxytrifluoromethylation of Alkenes

Year: 2013

Type: article

Abstract: Something radical: An efficient enantioselective oxytrifluoromethylation of alkenes has been developed using a copper catalyst system. Mechanistic studies are consistent with a metal-catalyzed redox radical addition mechanism in which a CO bond is formed by the copper-mediated enantioselective trapping of a prochiral alkyl radical intermediate derived from the initial trifluoromethyl radical addition.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201307790

Authors: Rong Zhu, Stephen L. Buchwald

Institution: Massachusetts Institute of Technology

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: G2858127696, CATALYTIC METHODS FOR ORGANIC SYNTHESIS, Catalytic Methods for Organic Synthesis