Work

Cytomolecular evaluation of structural chromosome instability in sows with decreased reproductive efficiency

Year: 2013

Type: article

Abstract: Cytomolecular evaluation of pig structural chromosome instability revealed excessive fragility of Xq21, Xq22 and Xq26 chromosome regions in sows with decreased reproductive efficiency. The highest frequency of structural defects was found in SSCXq26 genome region containing FRM1 gene locus with unstable trinucleotide CGG repeats which localization was assigned by in situ PCR method. The results obtained suggest that heterosome X instability may be a cause of defective expression of genes related to fertility, leading to a decrease of reproductive efficiency of sows. The presented outcomes can be used in further studies on cytomolecular background of chromosome instability phenomenon and their phenotypic effects in pigs.

Source: Journal of Animal Science Biology and Bioeconomy

Authors: B. Danielak‐Czech, A. Kozubska‐Sobocińska, Marek Babicz, K. Kruczek, B. Rejduch

Institutions: National Research Institute of Animal Production, University of Life Sciences in Lublin

Language: English

Topic: Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Zero hunger

Open Access status: diamond

OpenAlex ID: W2115844756

FWCI:

Cites: 24

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Related to: 10