Work

Evaluation of Analogs of Reutericyclin as Prospective Candidates for Treatment of Staphylococcal Skin Infections

Year: 2009

Type: article

Abstract: The potential for reutericyclin derivatives to be used as topical antibiotics to treat staphylococcal skin infections was investigated. All reutericyclins inhibited the growth of clinical isolates of drug-resistant Staphylococcus aureus. Unlike the standard topical agent mupirocin, most reutericyclin derivatives eradicated staphylococcal biofilms. Moreover, two compounds formulated in hydrophilic petrolatum (10%, wt/wt) were efficacious in treating S. aureus superficial skin infections in mice. These data exemplify the prospect of developing reutericyclins as new topical antibiotics.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00457-09

Authors: Julian G. Hurdle, Raghunandan Yendapally, Dianqing Sun, Richard E. Lee

Institution: University of Tennessee Health Science Center

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: East Tennessee State University, Health Science Center, University of Tennessee, National Institute of General Medical Sciences