Work

Avirulence of Candida albicans auxotrophic mutants in a rat model of oropharyngeal candidiasis

Year: 1995

Type: article

Abstract: The virulence of Candida albicans strain SC5413 and two isogenic derivatives have been investigated in a rat model of oropharyngeal candidiasis. The results demonstrate that both mutant strains are avirulent in this animal model while the parental strain readily initiates infection. Avirulence is not related to altered growth characteristics or the inability of the strains to undergo yeast-to-hyphal morphogenesis. The potential importance of nutritional sufficiency as a virulence factor as well as the possibility of utilizing such strains in the development of an in vitro expression technology system for Candida albicans is discussed.

Source: FEMS Microbiology Letters

DOI: 10.1016/0378-1097(95)00007-r

Authors: Michael F. Cole, William H. Bowen, Xiao-jiong Zhao, Ronald L. Cihlar

Institutions: Georgetown University, University of Rochester Medicine, University of Rochester

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Dental and Craniofacial Research