Regulatory B Cells Deficiency in Sclerotic-Type Cutaneous Chronic Graft-Versus-Host Disease
Year: 2014
Type: article
Abstract: Sclerotic-type chronic graft versus host disease (Scl-cGVHD) is a late manifestation of cGVHD that can lead to significant functional disability and morbidity. Scl-cGVHD is often refractory to treatment and its pathogenesis remains poorly understood. Recent studies on a murine model of Scl-cGVHD have proposed that regulatory B cells (Breg) may play a role in controlling development of early T cell infiltrates and later skin fibrosis skin. Although cGVHD has been associated with the presence of autoantibodies, elevated B cell activation factor, and increases in atypical B cell populations, alterations in Breg populations have not been explored.
Institutions: National Cancer Institute, National Institutes of Health
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2116525907