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Laser exposure of gold nanorods can induce intracellular calcium transients

Year: 2013

Type: article

Abstract: Uncoated and poly(styrene sulphonate) (PSS)-coated gold nanorods were taken up by NG108-15 neuronal cells. Exposure to 780 nm laser light at the plasmon resonance wavelength of the gold nanorods was found to induce intracellular Ca(2+) transients. The higher Ca(2+) peaks were observed at lower laser doses, with the highest levels obtained at a radiant exposure of 0.33 J/cm(2) . In contrast, the cells without nanoparticles showed a consistently small response, independent of the laser dose. These initial results open up new opportunities for peripheral nerve regeneration treatments and for more efficient optical stimulation techniques.

Source: Journal of Biophotonics

DOI: 10.1002/jbio.201300043

Authors: Chiara Paviolo, John W. Haycock, Peter J. Cadusch, Sally L. McArthur, Paul R. Stoddart

Institutions: Swinburne University of Technology, University of Sheffield

Language: English

Topic: Gold and Silver Nanoparticles Synthesis and Applications

Subfield: Electronic, Optical and Magnetic Materials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Biotechnology and Biological Sciences Research Council