Work

Bimodal MR–PET Agent for Quantitative pH Imaging

Year: 2010

Type: article

Abstract: Two unknowns: The relaxivity of activatable magnetic resonance (MR) contrast agents depends on environmental factors, such as the pH value or enzymatic activity, but the MR signal depends on relaxivity and agent concentration. Simultaneous positron emission tomography (PET) and MR imaging (MRI) with the bimodal, pH-responsive MR–PET agent shown enabled the direct determination of concentration and T1, and hence the pH value.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201000075

Authors: Luca Frullano, Ciprian Catana, Thomas Benner, A. Dean Sherry, Peter Caravan

Institutions: Harvard University, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, The University of Texas at Dallas

Language: English

Topic: Lanthanide and Transition Metal Complexes

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funders: National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources

Awards: G4077858590, G7964217458