Work

Synthesis and pharmacological evaluation of benzofuran-acetamides as “antineophobic” mitochondrial DBI receptor complex ligands

Year: 1998

Type: article

Abstract: A sries of novel benzofuran analogues of N,N-di-n-hexyl-2-phenylindole-3-acetamide (5, FGIN-1-27), a potent and highly specific mitochondrial DBI receptor complex ligand, were synthesized by a modified Fischer method and found in vitro and in vivo to be equally potent and selective as FGIN-1-27.

Source: Bioorganic & Medicinal Chemistry Letters

DOI: 10.1016/s0960-894x(98)00374-6

Authors: Yi Liao, Alan P. Kozikowski, Alessandro Guidotti, Erminio Costa

Institutions: Mayo Clinic, University of Groningen, Mayo Clinic in Florida, Georgetown University Medical Center, Georgetown University

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,880