Work

Quantum Dots with a Paramagnetic Coating as a Bimodal Molecular Imaging Probe

Year: 2005

Type: article

Abstract: MRI detectable and targeted quantum dots were developed. To that aim, quantum dots were coated with paramagnetic and pegylated lipids, which resulted in a relaxivity, r(1), of nearly 2000 mM(-1)s(-1) per quantum dot. The quantum dots were functionalized by covalently linking alphavbeta3-specific RGD peptides, and the specificity was assessed and confirmed on cultured endothelial cells. The bimodal character, the high relaxivity, and the specificity of this nanoparticulate probe make it an excellent contrast agent for molecular imaging purposes.

Source: Nano Letters

DOI: 10.1021/nl051935m

Authors: Willem J. M. Mulder, Rolf Koole, Ricardo J. Brandwijk, Gert Storm, Patrick T. K. Chin, Gustav J. Strijkers, Celso de Mello Donegá, Klaas Nicolay, Arjan W. Griffioen

Institutions: Utrecht University, Maastricht University Medical Centre, Maastricht University, Eindhoven University of Technology

Language: English

Topic: Quantum Dots Synthesis And Properties

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2116927089

FWCI: 21.54

Cites: 27

Cited by: 489

Related to: 9