Work

UnLINCing the nuclear envelope: towards an understanding of the physiological significance of nuclear positioning

Year: 2011

Type: review

Abstract: Appropriate tissue morphogenesis strictly requires the developmental regulation of different types of nuclear movements. LINC (linker of nucleoskeleton and cytoskeleton) complexes are macromolecular scaffolds that span the nuclear envelope and physically connect the nuclear interior to different cytoskeletal elements and molecular motors, thereby playing essential roles in nucleokinesis. Recent studies dedicated to the in vivo disruption of LINC complexes not only confirmed their widespread role in nuclear dynamics, but also led to a vigorous regain of interest in the physiological relevance of nuclear positioning within cells and syncitia. In the present paper, we review the results of LINC complex disruption in vivo across different organisms and the potential implications of observed phenotypes in human diseases.

Source: Biochemical Society Transactions

DOI: 10.1042/bst20110660

Authors: David Razafsky, Shulun Zang, Didier Hodzic

Institution: Washington University in St. Louis

Language: English

Topic: Nuclear Structure and Function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Eye Institute, National Institute of General Medical Sciences

Awards: The nucleus-cytoskeleton connection in health and disease, G1381428186, Core Grant for Vision Research, NUCLEAR DYNAMICS IN RETINAL DEVELOPMENT AND HOMEOSTASIS, Interdisciplinary Training in Vision Science