Vulnerability to depression: what is the role of stress genes in gene × environment interaction?
Year: 2009
Type: article
Abstract: Vulnerability to depression has been linked to the interaction of genetic predisposition with stressful life events. This review considers the associations between serotonergic and hypothalamic-pituitary-adrenal (HPA) systems. We follow the standpoint of a previous Editorial Review (Bhagwagar & Cowen, Psychological Medicine 2008, 38, 307-313) and consider another possible mechanism of vulnerability to depressive disorder, that is we suggest that the gene x environment interaction involves complex participation of serotonergic genes modulating response to stress through the HPA system.
Source: Psychological Medicine
Authors: W. El Hage, J. F. Powell, S. A. Surguladze
Language: English
Subfield: Behavioral Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
Funders: Servier, H. Lundbeck A/S, Cilag
OpenAlex ID: W2116991563