Year: 2009
Type: article
Abstract: Current research supports the strong potential of structural MRI profiles, even within cross-sectional designs, as a promising method for the discrimination of Alzheimer's Disease (AD) from normal controls and for the prediction of Mild Cognitive Impairment (MCI) progression and conversion to AD. Findings suggest that measures of structural change in mesial and lateral temporal, cingulate, parietal and midfrontal areas may facilitate the assessment of a treatment's ability to halt the progressive structural loss that accompanies clinical decline in MCI. The performance of prediction is likely to continue to improve with the incorporation of measures from other neuroimaging modalities, clinical assessments, and neuromedical biomarkers, as the regional profile of individuals at risk for progression is refined.
Source: Behavioural Neurology
DOI: 10.1155/2009/698156
Authors: Christine Fennema-Notestine, Linda K. McEvoy, Donald J. Hagler, Mark W. Jacobson, Anders M. Dale, the Alzheimer’s Disease Neuroimaging Initiative
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,790
Funders: Foundation for the National Institutes of Health, U.S. Department of Veterans Affairs, Alzheimer's Association, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, AstraZeneca, GlaxoSmithKline, Alzheimer's Disease Neuroimaging Initiative, Novartis Pharmaceuticals Corporation, Northern California Institute for Research and Education, Elan, Eisai, National Institutes of Health, U.S. Food and Drug Administration, University of California, Los Angeles, University of California, San Diego, National Institute on Aging, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources
Awards: G104586243, G1923530831, G2152643862, Structural & Metabolic Neuroimaging Biomarkers in Early Alzheimer's Disease, G2835601961, Morphometry Biomedical Informatics Research Network, G29951154, G3131374986, G3146424788, G3553156159, G3705772492, G3710456697, G43180419, G5207404921, G5209990037, G5389965057, The VETSA Longitudinal MRI Twin Study of Aging, Structure and Functional Imaging of Age-Related Changes in Working Memory, G5605366547, G5678256514, Alzheimer's Disease Neuroimaging Initiative, G613619302, G6161276258, G6259281481, G6899163935, G6957926738, G7414321945, G7799614282, G781725486, Alzheimer's Disease Cooperative Study, G839208290, G9000039018, G9000122335, G920654007
OpenAlex ID: W4255572204