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Equine Herpesvirus 1 Utilizes a Novel Herpesvirus Entry Receptor

Year: 2005

Type: article

Abstract: The well-described herpesvirus entry receptors HveA (TNFRSF14), HveB (nectin 2), and HveC (nectin 1) have been shown to mediate the entry of alphaherpesviruses. Our findings showed that the alphaherpesvirus equine herpesvirus 1 (EHV-1) efficiently entered and replicated in CHO-K1 cells that lack the entry receptors HveA, HveB, and HveC, demonstrating that EHV-1 utilizes a unique entry receptor. As with other alphaherpesviruses, efficient EHV-1 entry was dependent on glycoprotein D and cell surface glycosaminoglycans.

Source: Journal of Virology

DOI: 10.1128/jvi.79.5.3169-3173.2005

Authors: Arthur R. Frampton, William F. Goins, Justus B. Cohen, Jens von Einem, Nikolaus Osterrieder, Dennis J. O'Callaghan, Joseph C. Glorioso

Institutions: University of Pittsburgh, Cornell University, New York State College of Veterinary Medicine, Louisiana State University Health Sciences Center Shreveport

Language: English

Topic: Herpesvirus Infections and Treatments

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke, National Center for Research Resources

Awards: G1962780377, COBRE Center for Molecular and Tumor Virology, G3038019295, G4120550744, G5106902468, G6875692237, G7185013638, G8454712484, G9000314522

OpenAlex ID: W2117140759

FWCI: 1.962

Cites: 26

Cited by: 36

Related to: 10