Work

Pip92: A Short-Lived, Growth Factor-Inducible Protein in BALB/c 3T3 and PC12 Cells

Year: 1990

Type: article

Abstract: pip92 is a cellular immediate-early gene inducible by serum growth factors in fibroblasts. It is also induced in the rat pheochromocytoma cell line PC12 by agents that cause proliferation, neuronal differentiation, and membrane depolarization. We show that the pip92-encoded polypeptide is a proline-rich protein of 221 amino acids, has an extremely short half-life, and is localized in the cytoplasm. We hypothesize that Pip92 plays a role in mediating the cellular responses to a variety of extracellular signals.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.10.12.6769

Authors: C H Charles, J S Simske, T P O'Brien, L F Lau

Institution: University of Illinois Chicago

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute