Work

Interleukin-4 Up-Regulates Mouse Mammary Tumor Virus Expression yet Is Not Required for In Vivo Virus Spread

Year: 2001

Type: article

Abstract: The mouse mammary tumor virus (MMTV) superantigen induces T-cell production of cytokines, such as interleukin-4, which in turn increase MMTV transcription. However, interleukin-4 is not required for in vivo virus spread, because mice lacking interleukin-4 or the STAT6 transcription factor showed wild-type infection of lymphoid and mammary tissue. In spite of this, mammary tumor incidence was decreased in STAT6 null mice.

Source: Journal of Virology

DOI: 10.1128/jvi.75.23.11886-11890.2001

Authors: Jennifer Czarneski, Jennifer Meyers, Tao Peng, Valsamma Abraham, Rosemarie Mick, Susan R. Ross

Institution: University of Pennsylvania

Language: English

Topic: T-cell and Retrovirus Studies

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute