Work

Amniotic Membrane Transplantation for Persistent Epithelial Defects With Ulceration

Year: 1997

Type: article

Abstract: PURPOSE: To determine whether preserved human amniotic membrane can be used as an alternative substrate for treating persistent corneal epithelial defects with sterile ulceration. METHODS: Amniotic membrane transplantation was performed in 11 eyes of 11 consecutive patients with corneal ulcers of different causes that had persisted for a mean +/- SD of 17.5 +/- 13.9 weeks. RESULTS: Ten patients healed in 3.9 +/- 2.3 weeks (P < .01) without recurrence for 9.0 +/- 5.9 months. One patient failed to heal because of preexisting corneal perforation pursuant to severe rheumatoid arthritis. CONCLUSION: Amniotic membrane transplantation may be considered an alternative method for treating persistent epithelial defects and sterile ulceration that are refractory to conventional treatment and before considering treatment by conjunctival flaps or tarsorrhaphy.

Source: American Journal of Ophthalmology

DOI: 10.1016/s0002-9394(14)70125-4

Authors: SHWU-HUEY LEE, SCHEFFER C.G. TSENG

Institution: University of Miami

Language: English

Topic: Corneal Surgery and Treatments

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,300