Work

Lymph-migrating, tissue-derived dendritic cells are minor constituents within steady-state lymph nodes

Year: 2008

Type: article

Abstract: Observations that dendritic cells (DCs) constitutively enter afferent lymphatic vessels in many organs and that DCs in some tissues, such as the lung, turnover rapidly in the steady state have led to the concept that a major fraction of lymph node DCs are derived from migratory DCs that enter the lymph node through upstream afferent lymphatic vessels. We used the lysozyme M-Cre reporter mouse strain to assess the relationship of lymph node and nonlymphoid organ DCs. Our findings challenge the idea that a substantial proportion of lymph node DCs derive from the upstream tissue during homeostasis. Instead, our analysis suggests that nonlymphoid organ DCs comprise a major population of DCs within lymph nodes only after introduction of an inflammatory stimulus.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20081430

Authors: Claudia Jakubzick, Milena Bogunovic, Anthony J. Bonito, Emma L. Kuan, Miriam Merad, Gwendalyn J. Randolph

Institution: Icahn School of Medicine at Mount Sinai

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Heart Association, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases