Work

Heterologous Expression and Manipulation of Three Tetracycline Biosynthetic Pathways

Year: 2012

Type: article

Abstract: A very accommodating host: Three tetracycline biosynthetic pathways were overexpressed and manipulated in the heterologous host Streptomyces lividans K4-114. Through the inactivation of various genes and characterization of the resulting biosynthetic intermediates, new tetracycline-modifying enzymes were identified (see scheme).

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201205426

Authors: Peng Wang, Woncheol Kim, Lauren B. Pickens, Xue Gao, Yi Tang

Institution: University of California, Los Angeles

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: G3262617303, Biotechnology Training in Biomedical Sciences and Engineering