Work

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

Year: 2010

Type: preprint

Abstract: Although a developmental role for Hippo signaling in organ size control is well appreciated, how this pathway functions in tissue regeneration is largely unknown. Here we address this issue using a dextran sodium sulfate (DSS)-induced colonic regeneration model. We find that regenerating crypts express elevated Yes-associated protein (YAP) levels. Inactivation of YAP causes no obvious intestinal defects under normal homeostasis, but severely impairs DSS-induced intestinal regeneration. Conversely, hyperactivation of YAP results in widespread early-onset polyp formation following DSS treatment. Thus, the YAP oncoprotein must be exquisitely controlled in tissue regeneration to allow compensatory proliferation and prevent the intrinsic oncogenic potential of a tissue regeneration program.

Source: Genes & Development

DOI: 10.1101/gad.1978810

Authors: Jing Cai, Nailing Zhang, Yonggang Zheng, Roeland F. de Wilde, Anirban Maitra, Duojia Pan

Institutions: Howard Hughes Medical Institute, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Hippo pathway signaling and YAP/TAZ

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Howard Hughes Medical Institute, National Cancer Institute