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Analysis of mutations at position 184 in reverse transcriptase of human immunodeficiency virus type 1

Year: 1995

Type: article

Abstract: We have analyzed recombinant human immunodeficiency virus type 1 reverse transcriptases that contain mutations at position 184. These variants retain high levels of RNA-dependent DNA polymerase activity and show resistance to ddITP. However, the mutants varied in their ability to polymerize processively. The variants Met184Ile and Met184Val showed slight reductions in processivity relative to that of the wild-type enzyme; the variants Met184Ala and Met184Leu showed considerable reductions in their processivity.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.39.7.1624

Authors: P L Boyer, S H Hughes

Institution: National Cancer Institute

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2118095174

FWCI: 7.155

Cites: 37

Cited by: 103

Related to: 10