Work

Semi‐isometric Registration of Line Features for Flexible Fitting of Protein Structures

Year: 2010

Type: article

Abstract: In this paper, we study a registration problem that is motivated by a practical biology problem - fitting protein structures to low-resolution density maps. We consider registration between two sets of lines features (e.g., helices in the proteins) that have undergone not a single, but multiple isometric transformations (e.g., hinge-motions). The problem is further complicated by the presence of symmetry in each set. We formulate the problem as a clique-finding problem in a product graph, and propose a heuristic solution that includes a fast clique-finding algorithm unique to the structure of this graph. When tested on a suite of real protein structures, the algorithm achieved high accuracy even for very large inputs containing hundreds of helices.

Source: Computer Graphics Forum

DOI: 10.1111/j.1467-8659.2010.01813.x

Authors: S.S. Abeysinghe, M. L. Baker, W. Chiu, T. Ju

Institutions: Washington University in St. Louis, Baylor College of Medicine

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, National Center for Research Resources

Award: G1688340195