Yoga lifestyle intervention reduces blood pressure in HIV‐infected adults with cardiovascular disease risk factors*
Year: 2010
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: OBJECTIVE: People living with HIV infection are at increased risk for developing cardiovascular disease (CVD). Safe and effective interventions for lowering CVD risk in HIV infection are high priorities. We conducted a prospective, randomized, controlled study to evaluate whether a yoga lifestyle intervention improves CVD risk factors, virological or immunological status, or quality of life (QOL) in HIV-infected adults relative to standard of care treatment in a matched control group. METHODS: Sixty HIV-infected adults with mild-moderate CVD risk were assigned to 20 weeks of supervised yoga practice or standard of care treatment. Baseline and week 20 measures were: 2-h oral glucose tolerance test with insulin monitoring, body composition, fasting serum lipid/lipoprotein profile, resting blood pressures, CD4 T-cell count and plasma HIV RNA, and the Medical Outcomes Study Short Form (SF)-36 health-related QOL inventory. RESULTS: Resting systolic and diastolic blood pressures improved more (P=0.04) in the yoga group (-5 +/- 2 and -3 +/- 1 mmHg, respectively) than in the standard of care group (+1 +/- 2 and+2 +/- 2 mmHg, respectively). However, there was no greater reduction in body weight, fat mass or proatherogenic lipids, or improvements in glucose tolerance or overall QOL after yoga. Immune and virological status was not adversely affected. CONCLUSION: Among traditional lifestyle modifications, yoga is a low-cost, simple to administer, nonpharmacological, popular behavioural intervention that can lower blood pressure in pre-hypertensive HIV-infected adults with mild-moderate CVD risk factors.
Source: HIV Medicine
Institution: Washington University in St. Louis
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences, National Center for Complementary and Integrative Health
Awards: G1123597226, WASHINGTON UNIVERSITY AIDS CLINICAL TRIALS UNIT, Characterizing the HIV-Muscle Mitochondrial Proteme, G1578241593, WASHINGTON UNIVERSITY AIDS CLINICAL TRIALS UNIT, Yoga for the Management of HIV-Metabolic Syndromes, Diabetes Research & Training Center, G2135258891, G2199452652, G2743333773, EXERCISE AND PIOGLITAZONE FOR HIV CARDIOMETABOLIC SYNDROMES, G3563133777, G3732380844, G443757094, G4467312596, G447438240, HIV, Endothelial Dysfunction, and Insulin Resistance, Exercise and TZD Effects on Myocardial Substrate Metabolism and Function in HIV, G4621590637, Metabolic Abnormalities in HIV, Myocardial Function and FFA Metabolism in HIV Metabolic Syndrome, Washington University Institute of Clinical and Translational Sciences, Exercise & Pioglitazone for HIV-Metabolic Syndromes, G766674393, Washington University Institute of Clinical and Translational Sciences (UL1), G87705910, Washington University Nutrition Obesity Research Center, Diabetes Research Center, GENERAL CLINICAL RESEARCH CENTER
OpenAlex ID: W2118208876