Work

Beyond VEGF: Inhibition of the Fibroblast Growth Factor Pathway and Antiangiogenesis

Year: 2011

Type: review

Abstract: Fibroblast growth factor (FGF) signaling regulates cell proliferation, differentiation, survival, angiogenesis, and wound healing. Compelling evidence for deregulated FGF signaling in tumorigenesis continues to emerge, and a growing body of research suggests that FGF may also play an integral role in the resistance to anti-VEGF therapy. Although agents targeting FGF signaling are early in development, the potential to target both the VEGF and FGF pathways may translate into improvements in the clinical care of cancer patients.

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-11-0659

Authors: Christopher Lieu, John Heymach, Michael Overman, Hai Tran, Scott Kopetz

Institution: The University of Texas MD Anderson Cancer Center

Language: English

Topic: Fibroblast Growth Factor Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Conquer Cancer Foundation, National Institutes of Health, National Cancer Institute, National Center for Advancing Translational Sciences