Work

C-Type Lectins DC-SIGN and L-SIGN Mediate Cellular Entry by Ebola Virus in cis and in trans

Year: 2002

Type: article

Abstract: Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped lentiviral particles and transmitting infection to susceptible cells. Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection.

Source: Journal of Virology

DOI: 10.1128/jvi.76.13.6841-6844.2002

Authors: Carmen P. Alvarez, Fátima Lasala, Jaime Carrillo, Oscar Muñiz, Angel L. Corbí, Rafael Delgado

Institutions: Hospital Universitario 12 De Octubre, Consejo Superior de Investigaciones Científicas

Language: English

Topic: Viral Infections and Outbreaks Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2118364979

FWCI: 25.9

Cites: 17

Cited by: 670

Related to: 9