Work

Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors

Year: 2014

Type: article

Abstract: Autophagy is a conserved cellular process that involves the degradation of cellular components for energy maintenance and cytoplasmic quality control that has recently gained interest as a novel target for a variety of human diseases, including cancer. A prime candidate to determine the potential therapeutic benefit of targeting autophagy is the kinase ULK1, whose activation initiates autophagy. Here, we report the first structures of ULK1, in complex with multiple potent inhibitors. These structures show features unique to the enzyme and will provide a path for the rational design of selective compounds as cellular probes and potential therapeutics.

Source: ACS Chemical Biology

DOI: 10.1021/cb500835z

Authors: Michael B. Lazarus, Chris J. Novotny, Kevan M. Shokat

Institutions: Howard Hughes Medical Institute, University of California, San Francisco

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500