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Corticosterone enhances CSD susceptibility via glucocorticoid receptor activation in familial hemiplegic migraine 1 Cacna1a knock-in mice

Year: 2013
Type: article
Abstract: FHM1 mutant mice carrying the R192Q gain-of-function mutation in CaV2.1 (P/Q-type) calcium channels display enhanced glutamatergic transmission and increased propensity for cortical spreading depression (CSD;1,2). Corticosteroids released after stress also enhance glutamatergic transmission but the relationship between stress and migraine is not well understood.
DOI: 10.1186/1129-2377-14-s1-p85
Authors: R Shyti, K Eikermann-Haerter, OC Meijer, SH van Heiningen, L De Groote, MD Ferrari, C Ayata, AMJ van den Maagdenberg, EA Tolner
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,990
OpenAlex ID: W2118406412
FWCI:
Cites: 2
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Related to: 10