Work

Pathobiology of experimental acute pancreatitis.

Year: 1992

Type: article

Abstract: Pancreatic duct obstruction, even in the absence of biliary obstruction and/or bile reflux into the pancreatic duct, can trigger acute hemorrhagic necrotizing pancreatitis. The earliest changes are seen within acinar cells. Early derangements in acinar cell biology include inhibition of digestive enzyme secretion and the co-localization of lysosomal hydrolases with digestive enzyme zymogens. Under appropriate conditions, this co-localization could lead to digestive enzyme activation within acinar cells.

Source: PubMed Central

Author: M L Steer

Institution: Harvard University

Language: English

Topic: Pancreatitis Pathology and Treatment

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health

Awards: ACUTE PANCREATITIS, STIMULUS-SECRETION COUPLING IN THE EXOCRINE PANCREAS