Work

In Vitro Activities of Iboga Alkaloid Congeners Coronaridine and 18-Methoxycoronaridine againstLeishmania amazonensis

Year: 2002

Type: article

Abstract: In previous studies, we demonstrated the leishmanicide effect of coronaridine, a natural indole alkaloid isolated from stem bark of Peschiera australis (Delorenzi et al., Antimicrob. Agents Chemother. 45:1349-1354, 2001). In this study we show the leishmanicidal effect of the synthetic coronaridine and its racemic 18-methoxylated analog, 18-methoxycoronaridine. Both alkaloids revealed a potent leishmanicide effect against Leishmania amazonensis, a causative agent of cutaneous and diffuse cutaneous leishmaniasis in the New World. Despite their potent leishmanicide effect, both alkaloids were neither toxic to murine macrophages nor did they modulate their oxidative or cytokine production responses.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.46.7.2111-2115.2002

Authors: Jan Carlo Delorenzi, Leonardo Freire-de-Lima, Cerli R. Gattass, Deise de Andrade Costa, Liwen He, Martin E. Kuehne, Elvira M. B. Saraiva

Institutions: Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, University of Vermont

Language: English

Topic: Research on Leishmaniasis Studies

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2118483924

FWCI: 2.006

Cites: 41

Cited by: 55

Related to: 10