Human Leukocyte Antigen Class I and II Alleles and Overall Survival in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma
Year: 2011
Type: article
Study design: Observational Study
Abstract: Genetic variation in the 6p21 chromosomal region, including human leukocyte antigen (HLA) genes and tumor necrosis factor (TNF), has been linked to both etiology and clinical outcomes of lymphomas. We estimated the effects of HLA class I (A, B, and C), class II DRB1 alleles, and the ancestral haplotype (AH) 8.1 (HLAA*01-B*08-DRB1*03-TNF-308A) on overall survival (OS) among patients with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in a population-based study of non-Hodgkin lymphoma. During a median followup of 89 months, 31% (52 of 166) DLBCL and 28% (46 of 165) FL patients died. Using multivariate Cox regression models, we observed statistically significant associations between genetic variants and survival: HLA-Cw*07:01 was associated with poorer OS among DLBCL patients (Hazard ratio [HR] = 1.76, 95% confidence interval [CI] = 1.01-3.05); HLA-A*01:01 was associated with poorer OS (HR = 2.23, 95% CI = 1.24-4.01), and HLA-DRB1*13 (HR = 0.12, 95% CI = 0.02-0.90) and HLA-B Bw4 (HR = 0.36, 95% CI = 0.20-0.63) with better OS among FL patients. These results support a role for HLA in the prognosis of DLBCL and FL and represent a promising class of prognostic factors that warrants further evaluation.
Source: The Scientific World JOURNAL
DOI: 10.1100/2011/373876
Institutions: City Of Hope National Medical Center, City of Hope, Beckman Research Institute, National Research Centre, Mayo Clinic, National Institutes of Health, Division of Cancer Epidemiology and Genetics, Wayne State University, The Barbara Ann Karmanos Cancer Institute, University of Washington, Fred Hutch Cancer Center, University of Southern California, USC Norris Comprehensive Cancer Center
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $860
Awards: SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM, G1041864957, G1220193100, SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM, G1788914148, SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS--SEER, SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM, G3503792436, G386607036, G420411562, G4585269469, Immunogenetics of Non-Hodgkin Lymphoma Survival, G4836174358, G490749545, G5185757912, G5372537626, G5888954722, G7752797991, G835684289, G9000077506
OpenAlex ID: W2118721376