Year: 2005
Type: article
Study design: Observational Study
Abstract: Significant relationships have been reported between midsagittal areas of the corpus callosum and the degree of interhemispheric transfer, functional lateralization and structural brain asymmetries. No study, however, has examined whether parasagittal callosal asymmetries (i.e. those close to the midline of the brain), which may be of specific functional consequence, are present in the human brain. Thus, we applied magnetic resonance imaging and novel computational surface-based methods to encode hemispheric differences in callosal thickness at a very high resolution. Discrete callosal areas were also compared between the hemispheres. Furthermore, acknowledging the frequently reported sex differences in callosal morphology, parasagittal callosal asymmetries were examined within each gender. Results showed significant rightward asymmetries of callosal thickness predominantly in the anterior body and anterior third of the callosum, suggesting a more diffuse functional organization of callosal projections in the right hemisphere. Asymmetries were increased in men, supporting the assumption of a sexually dimorphic organization of male and female brains that involves hemispheric relations and is reflected in the organization and distribution of callosal fibers.
Source: Cerebral Cortex
Institutions: University of California, Los Angeles, University of Zurich
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,038
Funders: National Alliance for Research on Schizophrenia and Depression, National Institutes of Health, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, U.S. National Library of Medicine, National Center for Research Resources
Awards: G2627450486, Computational Anatomy and Multidimensional Modeling, Algorithms to Map Disease &Genetic Effects on the Brain, G3358825570, Novel PDEs for Cortical Mapping and Analysis in Disease, G3642348494, G4071066094, A Probabilistic Reference System for the Human Brain, G4524382552, A Multidimensional Alzheimer's Disease Brain Atlas, General Clinical Research Center, G4931376218, Center for Computational Biology (CCB)(RMI), HEMISPERIC: SPECIALIZATION AND INTERACTION, Psychological Research on Schizophrenic Conditions, G7567887838, Computional Brain Biology from Genotype to Phenotype
OpenAlex ID: W2118752846