Year: 2009
Type: article
Study design: Observational Study
Abstract: Background : The 3-hydroxy-3-methylglutaryl-coenzyme (HMG-Co-A) reductase inhibitors, also known as statins, \nare the most effective class of drugs for lowering serum Low-Density Lipoprotein cholesterol (LDL-c)concentrations. They are first-line agents for patients who require drug therapy to reduce serum LDL-c concentrations. Although these drugs have been very successful in managing the cardiovascular health of many patients, there are also potential adverse effects that have been identified. The most common adverse effects reported include muscle pain or weakness that can progress to rhabdomyolysis and mortality. If detected early, statin-related symptoms are reversible after withdrawal of the statin. \nObjective : This research was aimed to know the safety of statin used at Public Hospitals in Yogyakarta. \nMethod : This research was observational study with retrospective data collected. The target population are all of diabetes mellitus, cardiovascular and stroke patients that recorded on the medical record of Public Hospitals in \nYogyakarta during 2 months. \nResults : There were 28 patients who used simvastatin and 8 patients who used atorvastatin, experienced adverse \neffects of statins (n=157). Headache was the most adverse effect which was experienced by the patients. However rhabdomyolysis was not found in this reasearh. Interaction between simvastatin and nifedipine resulted more adverse effects such as headache, insomnia and abdominal pain than with other drugs. \nConclusions : Simvastatin, rosuvastatin and atorvastatin were well tolerated use in Yogyakarta, Indonesia. Only 22.9% \nfrom 157 patients experienced the adverse effects of statin. Adverse effects because of the interaction between \nsimvastatin and other drugs were experienced by 8.92% patients. The result of this study need to be confirmed with \nadditional study with larger sample sizes and vigilant surveillance to abolish the toxicity of the statin.
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2118765039